Clinico-Haematological Profile of Thalassemia Intermedia Patients

Thalassemia intermedia.

Thalassemia intermedia is a clinical definition applied to patients whose clinical phenotype is milder than that of thalassemia major. Criteria used to define thalassemia intermedia including age at presentation, hemoglobin or fetal hemoglobin levels and transfusion independence, are unsatisfactory. The possibility of typing the molecular defect allows a retrospective analysis of patients and o...

Echocardiographic Evaluation of Thalassemia Intermedia Patients in

Pulmonary thromboembolism in thalassemia intermedia patients.

hybrid (myeloid-erythroid) blasts has been proposed to be a characteristic bone marrow feature in EL, but has not as yet been emphasized as a morphologic feature of the disease.4 Erythroblasts with peripheral chromatin condensation are sufficiently characteristic for a provisional diagnosis of B 19 infection to be made on the histology5 and rare erythroblasts with this morphologic feature could...

CMR survey in Thalassemia Intermedia patients

Results One-hundred and eighty-eight (74.6%) patients showed no MIO in any segment, 56 (22%) had an heterogeneous distribution (52 with global heart T2*≥20 ms), and 8 (0.3%) showed an homogeneous MIO. Left ventricular (LV) and right ventricular (RV) dilatations were present in 113 (45%) and in 49 (19%) patients, respectively. LV dysfunction was present in the 18.0% of the cases while RV dysfunc...

Evaluation of Cardiac Function in Patients with Thalassemia Intermedia

Abstract Background Thalassemia intermedia is a variety of beta thalassemia which shows clinical symptoms somewhere between asymptomatic carriers and thalassemia major. Cardiac dysfunctions due to chronic anemia and hemosiderosis are the major causes of death in these patients. The purpose of this study is to evaluate cardiac function in these patients by echocardiography. Materials and Met...